Here's a link to an interesting article in a 2011 Hot Rod Magazine describing the build for a Buick 300 that develops lots of horsepower.
http://www.hotrod.com/how-to/engine/hrdp-1103-how-to-hot-rod-any-engine/
Link does not go to Hotrod.com, but to a phony spam malware site, beware!!!!
Better scan your computer, Harold. The link works fine.
Phil I think Chris Gill's 300 Stroker build will be better. After he figures out the Megasquirt setup. 300 Stroker build on Mgexperience site.